The 29-year-old was ruled out of his side's 4-2 defeat against Real Sociedad and did not play for Portugal over the recent international break due to injury.
Javier Hernandez, who has joined the club on loan from Manchester United, could make his debut after being named on the bench.
Real Madrid: Casilas; Pepe, Ramos, Coentrao, Arbeloa; Modric, Kroos; James, Bale, Ronaldo; Benzema
Atletico Madrid: Moya; Juanfran, Godin, Miranda, Siqueira; Gabi, Tiago, Koke, Garcia; Jimenez, Mandzukic
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