The outcome of this weekend's encounter could prove crucial in terms of the race for survival as the Royals currently sit one point below their Midlands rivals, who are third from bottom in the table.
Reading and Villa both head into Saturday's game with just one win in their last five fixtures, which consist of three defeats and a draw, but Villa were able to clinch a slender 1-0 victory over Reading in November.
Aston Villa: LLWDL
Possible starting lineups
Reading: Taylor; Kelly, Mariappa, Pearce, Harte; Kebe, Leigertwood, Akpan, McAnuff; Le Fondre, Hunt
Aston Villa: Guzan; Lowton, Clark, Baker, Bennett; Weimann, Westwood, Sylla, Agbonlahor; N'Zogbia; Benteke
Sports Mole says: 1-2