Captain Rooney makes his first league start for United after spending two months out with injury, but will play on the right wing as Marcus Rashford retains his place up front.
Louis van Gaal makes only one other change to the side that were defeated 3-0 at Tottenham Hotspur last time out, dropping promising young defender Timothy Fosu-Mensah to the bench in favour of Antonio Valencia.
For the visiting Villans, who will be relegated should they fail to win at Old Trafford today, caretaker Eric Black makes just one alteration to the XI that were defeated by Bournemouth last weekend.
Manchester United: De Gea; Valencia, Smalling, Blind, Rojo; Schneiderlin, Fellaini; Mata, Rooney, Memphis; Rashford
Subs: Romero, Darmian, Fosu-Mensah, McNair, Young, Lingard, Martial
Aston Villa: Guzan; Hutton, Clark, Lescott, Cissokho; Bacuna, Westwood, Gana, Richardson; Sinclair; Ayew
Subs: Richards, Sanchez, Gil, Bunn, Lyden, Gestede, Grealish
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