City, who host Fulham this weekend, will play one of their three games in hand on leaders Chelsea when they make the trip to Old Trafford on March 25.
If they manage to earn a win at the home of their local rivals, the Blues will take a step closer to going top of the table.
"That game can change everything," Fernandinho is quoted as saying by Sky Sports News. "I hope our team will be ready and we can walk the streets without any problems and that our fans can give us some hugs afterwards.
"When you win these games, you can walk down the street, but not when you lose. I think the game will be beautiful - I just hope we play very well."
City thrashed United 4-1 at the Etihad Stadium in the reverse fixture six months ago.