As it was, a fourth-minute header from Daniel Sturridge was enough for the home side to record a 1-0 victory over the champions, who failed to turn possession into goals during the second half.
You can find out how the match unfolded with our minute-by-minute updates below.
"It's disappointing obviously but whatever has happened has happened and we can't go back now. We have quality players that can fill the void," he said.
MAN UNITED: Lindegaard, Anderson, Smalling, Hernandez, Nani, Valencia, Buttner
"The first 30 minutes - we always felt if you got through that and you weren't down, then you always got stronger in the game. The second half always felt much more comfortable playing here. The first half is very, very difficult."
"He got a cut down the middle of his forehead, completely accidental, but it's quite a bad cut I have to say. It will probably keep him out for a few weeks. He would have started to today so we've had to alter [the team] a bit, but not too much," he told Sky Sports News.
Moyes also added that Rooney is highly unlikely to join up with the England squad for their World Cup qualifiers against Moldova and Ukraine.
"There is a different feel to this game. This is about two cities and fighting for the people in your city. It's important to focus on the game and our composure. You need to be competitive and fierce, but also retain that composure to play that football that you want to play."
"Could watch Coutinho all day. Fabulous little player."
"Manchester United, in the final third, have been very poor. Liverpool have got players behind the ball and defended well. But a warning to Liverpool is that you don't imagine United can be as bad in the second half."