Foxes boss Craig Shakespeare, confirmed at the helm of the Premier League champions until the end of the season, will be hoping to make it three wins on the trot under his stewardship.
Nampalys Mendy is sidelined for the second leg at the King Power Stadium after the midfielder sustained a knee injury in training.
Meanwhile Sevilla, leading 2-1 from the first leg at the Ramon Sanchez Pizjuan, have made eight changes from the starting XI that drew 1-1 with Leganes on Saturday.
Leicester City: Schmeichel, Simpson, Huth, Morgan, Fuchs, Albrighton, Ndidi, Drinkwater, Mahrez, Okazaki, Vardy
Subs: Zieler, Chilwell, Amartey, King, Gray, Slimani, Ulloa
Sevilla: Rico, Mercado, Pareja, Rami, Sarabia, Iborra, N'Zonzi, Escudero, Vitolo, Nasri, Ben Yedder
Subs: Soria, Ferreira, Kranevitter, Corra, Jovetic, Vazquez, Lenglet
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