The Tangerines, who have only picked up two points on their travels so far this season, made a perfect start when Donervon Daniels's long pass was brought down by Ishmael Miller before the forward poked the ball past Marcus Bettinelli.
© Getty Images
Fulham, perhaps stunned by the early goal, almost fell further behind before the game reached the five-minute mark as Miller was again afforded space to shoot by the home side's defence, but this time his effort was blocked.
Blackpool continued to show promise in attack and Norwich City loanee Jacob Murphy unleashed an effort from distance that was only inches away from giving the Fylde club a second of the night.
The Whites were made to pay for their missed opportunities as Blackpool extended their lead when Miller again ran at the home team's backline before laying the ball off to Murphy, who scored a debut goal from close range.