La Viola have a fine recent record against the Friulian side and will hope for it to remain intact, as they search desperately for some consistent form under coach Beppe Iachini.
Fiorentina are unbeaten in their last eight league matches against Udinese, registering five wins and the same number of clean sheets in the process - their last defeat came back in 2016.
They have also won each of their last 12 home games against Sunday's visitors; in fact, only Juventus (with 35) have won more home games than Fiorentina (29) against Udinese in Serie A history.
Precedent will count for little, though, if Iachini's men continue to toil through the opening part of the season.
Last week, they enjoyed a perfect start against promoted Spezia - netting twice in the first five minutes through defenders German Pezzella and Cristiano Biraghi- but they then contrived to squander that advantage, only drawing 2-2 in the end.
Such wild inconsistency has characterised Fiorentina's play so far, undermining their stated aim of contending for European football next year.
Their underwhelming start has already prompted so-called 'crisis talks'; Iachini coming together with ambitious club president Rocco Commisso and sporting director Daniele Prade to discuss matters during the week.
Though they have scored the opening goal in three of their four games, turning the early advantage into points has proved more challenging.
Their northern counterparts have, too, endured a tough start to the campaign. They are buoyed, though, by a last-gasp 3-2 win against Parma last weekend and will hope to build on that first win of 2020-21 in Florence.
Udinese were missing regulars such as Rolando Mandragora, Juan Musso, Walace, Mato Jajalo, Jens Stryger Larsen and Dutch defender Bram Nuytinck against the Gialloblu, but fought hard to seal the win through winger Ignacio Pussetto's goal.
The Bianconeri will be wary, however, as they have conceded the first goal of the match in all four of their Serie A games this season - in stark contrast to Fiorentina's fast starts.
They have struggled to effectively defend in wide areas this term due to Gotti's propensity to select physically imposing but less mobile central defenders. The most fruitful avenue of attack against them is likely to be for Fiorentina's tricky wide men to cut inside and run at their less agile opponents.
That much-needed win, in week four, leaves the Zebrette in 17th place in the table, with a season-long battle against relegation most likely on the cards. They do lead Serie A in successful dribbles per game, largely thanks to the input of the mercurial De Paul, and offer a significant threat at set pieces.
With pressure weighing most heavily on the home side, Udinese may well feel that they can overcome continuing injury problems to steal something from this game.
An intriguing clash, amid the autumnal beauty of Tuscany, will be the 100th competitive meeting between the two clubs, dating back to the 1930s, and promises to be a closely contested affair.
Fiorentina Serie A form: WLLD
Udinese Serie A form: LLLW
Iachini will at least have the majority of his squad to choose from - a rarity in these times. There may well be a change in midfield, where ex-Verona man Amrabat has struggled as the holding player - Erick Pulgar and Alfred Duncan are breathing down his neck for a start.
Udinese manager Luca Gotti faces some major selection headaches, especially at the back. First choice goalkeeper Musso (knee), Nuytinck (hamstring), Kevin Bonifazi and Sebastian Prodl are unavailable, while wing-back Stryger Larsen is still missing.
Fiorentina possible starting lineup:
Dragowski; Milenkovic, Pezzella, Caceres; Callejon, Bonaventura, Amrabat, Castrovilli, Biraghi; Kouame, Ribery
Udinese possible starting lineup:
Nicolas; Becao, De Maio, Samir; ter Avest, De Paul, Arslan, Pereyra, Ouwejan; Lasagna, Okaka
We say: Fiorentina 1-0 Udinese
Hosts Fiorentina will see this as a game they simply must win, given Udinese's treatment table troubles and misfiring attack.
The under-pressure Tuscan side can edge a tight affair, thanks to their superior attacking capabilities: Jose Callejon's return to full fitness, in particular, could give Franck Ribery some much appreciated assistance in the creative department at the Artemio Franchi.