Utrecht then shot themselves in the foot when Mark van der Maarel was sent off after accruing two bookings in quick succession midway through the first half.
The latter misdemeanour also gifted PSV a penalty which Memphis Depay converted to double PSV's lead.
Things were to get worse for the hosts just two minutes later when Jorrit Hendrix scored his side's third goal to all but kill off the game.
However, PSV turned up the heat in the final stages and added a fourth when Christian Kum put through his own net with nine minutes left.
Georginio Wijnaldum subsequently finished off the rout with a fifth in injury time.