The opening 15 minutes went by without a decent effort on goal for either side, but Frankfurt missed the chance to take the lead when Stephan Schrock found Jan Rosenthal in the box, who hammered his shot over.
Armin Veh's side went close again moments later. The ball bobbled around in the area from a corner, before Marco Russ managed to direct a shot at goal. However, a combination of defender and goalkeeper saved APOEL.
Frankfurt continued to pose a threat, but the same could not be said of their opponents, who lacked a cutting edge going forward in the first half.
However, Frankfurt broke the deadlock with 67 minutes gone. Djakpa dummied the ball before curling it to the far post where Schrock headed home.
It was 2-0 shortly after. Schrock was brought down outside the box and Djakpa lifted his shot over the wall and under the crossbar.