The home side, who occupy 20th position, sit just three points above the relegation zone, while the Rams remain in trouble after their heavy defeat at Cardiff City on Tuesday night.
Nevertheless, the Rams still have much work ahead if they wish to remain in the division, particularly after their setback at the hands of Cardiff in midweek.
Even though Rooney took the opportunity to rest a number of key men, it highlighted that the England legend may have to become heavily reliant on his senior figures in the weeks ahead.
On the back of four points being claimed from as many matches, Derby still have distance between themselves and the relegation zone, but they can ill-afford to lose out to opponents who will sense a chance to make significant headway up the table.
Mark Robins will not be happy with his side's recent run of form, their only win in nine matches coming against promotion contenders Brentford.
However, while the Sky Blues have managed to stay out of the bottom three, that task has been made harder courtesy of their late defeat to Middlesbrough on Tuesday night.
The setback marked the second time in five home fixtures that Coventry had lost from a winning position, the other occasion coming versus Nottingham Forest at the start of February.
Although Robins will have few complaints with how his players are staying competitive in matches, their lack of a ruthless streak threatens to undermine their overall performances.
Coventry have not scored more than twice in a game since December 5, a period stretching 19 matches in all competitions.
Coventry City Championship form: LLWLDL
Derby County Championship form: WWLWDL
Rooney will make several changes to his Derby XI, including handing a recall to forward Colin Kazim-Richards.
Coventry are still without key defender Leo Ostigard, who serves the final game of his suspension.
Matty James could return to the team after his outing as a substitute in midweek, but Robins is unlikely to make major alterations.
Coventry City possible starting lineup:
Wilson; Hyam, McFadzean, Rose; Dabo, James, Hamer, McCallum; O'Hare; Walker, Biamou
Derby County possible starting lineup:
Roos; Byrne, Wisdom, Clarke, Buchanan; Bird, Shinnie; Jozwiak, Knight, Sibley; Kazim-Richards
We say: Coventry City 1-1 Derby County
Wary of Rotherham's games in hand, do not expect this encounter to be packed with action at either end. With that in mind, we are backing a low-scoring draw between two clubs who will not want to end the week without an extra point on the board.