Barkley had a strong start to his loan spell in the Midlands, but his performances quickly dropped off as the Villains suffered a dip in form, with the likes of John McGinn playing a much more important role in the middle throughout the campaign.
They will shield goalkeeper Emiliano Martinez, who has shone since his move from Arsenal with 15 Premier League clean sheets so far in his first season in the Midlands.
The Villains' talisman Jack Grealish made his first start since his recovery from a shin injury in that 2-1 win, and their captain should play a key role in the attack again.
He will support Ollie Watkins, who scored the winner last time out to take his tally to 14 league goals for the season alongside five assists in his first campaign in the top flight after a move from Brentford at the beginning of the season.
Aston Villa possible starting XI: Martinez; Konsa, Hause, Mings, Targett; Nakamba, McGinn; Traore, Grealish, El Ghazi; Watkins