Recording maximum points since September 28 has moved the Blues into third position in the standings, one point ahead of Saturday's opponents.
However, Frank Lampard is preparing for the game in the North-West with a number of issues remaining in the treatment room, as well as having a dilemma over which formation to use for one of their toughest tests of the campaign.
Here, Sports Mole predicts how Chelsea could line up for the showdown with the top-flight champions.
While Lampard has frequently used one creative midfielder as part of a three-man combination this season, the Englishman may instead opt to use Jorginho, N'Golo Kante and Mateo Kovacic for a game of this magnitude.
Should Lampard decide on that approach, Mason Mount may drop down to the substitutes' bench, providing that Christian Pulisic has shaken off a hip injury.
Ross Barkley may feature in the squad after an ankle problem, although the playmaker is only likely to make the bench.