Corry Evans has returned from suspension and comes straight back into the side to replace Lee Williamson in midfield. Meanwhile, Bowyer has kept the same back four that provided a shutout against Birmingham City, while Jordan Rhodes leads the line in attack.
Brentford boss Lee Carsley has stuck with the same team that lost their last outing 2-0 to Hull City during the week.
Alan Judge has not been deemed fit enough to return to the lineup as he continues to struggle with a hamstring problem, and as a result Marco Djuricin, Lasse Vibe and Jon Swift lead the line in attack.
Blackburn Rovers: Steele; Marshall, Duffy, Hanley, Olsson; Taylor, Evans, Akpan, Conway, Lawrence; Rhodes
Subs: Eastwood, Henley, Spurr, Kilgallon, Delfouneso, Koita, Williamson
Brentford: Button; Yennaris, Dean, Tarkowski, Bidwell; Woods, Diagouraga, McCormack; Vibe, Djuricin, Swift
Subs: Bonham, Saunders, Hofman, O'Connell, Gogia, Kerschbaumer, Canos