After the first game ended 1-1 at the Camp Nou a week ago, Barcelona head into the game on the back foot, but Fabregas insists that the Catalan club have the players to reach the final four of the competition.
"It will be a very difficult match, but we have the team to beat Atletico," the Spaniard told reporters. "We have to compete hard and we have the players that are more than capable to do that.
"We don't enjoy playing Atletico. They have a very well-defined style. Tomorrow we have to play like Barcelona more than ever. We need to score if we want to remain a big club and move to semis."
Barcelona have failed to beat Atletico in four previous meetings this season.