Both attackers have been purchased in big-money moves from Bayern Munich and Real Sociedad respectively to counteract the departure of last season's top goalscorer Diego Costa.
Los Franjirrojos's squad has been boosted by the summer acquisitions of Chelsea winger Gael Kakuta and Swansea City winger Alejandro Pozuelo, with both likely to feature at the Campo de Futbol de Vallecas.
Rayo Vallecano: WDDLW
Atletico Madrid: DWWWD
Possible starting lineups
Rayo Vallecano: Cobeno; Tito, Nacho, Ba, Amaya; Trashorras, Kakuta, Lass, Pozuelo; Manucho
Atletico Madrid: Moya; Miranda, Juanfran, Guilherme Siqueira, Godin, Gabi, Mario Suarez, Raul Garcia, Griezmann, Koke, Mandzukic
Sports Mole says: 1-3