The visitors took a one-goal lead into the interval following a close-range header from Raul Garcia.
Both sides had chances to add to the scoring in the second 45 minutes, but it remained 1-0 as Atletico took another big step towards the league title.
The capital outfit finished the match with 10 men, however, following a late red card for Juanfran.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
VALENCIA: Guaita; Joao, Costa, Mathieu; Gaya; Fuego, Parejo; Barragan, Jonas, Piatti; Alcacer
ATLETICO: Courtois; Juanfran, Miranda, Godin, Filipe; Tiago, Gabi; Koke, Garcia, Villa; Costa