The French midfielder is the Eagles' top scorer this season but sustained an injury during his return from suspension in the FA Cup against Southampton on Saturday.
Villa, meanwhile, have made four changes to the side that were held by League Two side Wycombe Wanderers at Adams Park on Saturday as Remi Garde goes in search of his first win in charge of the club.
Micah Richards, who scored against Wycombe but was then involved in an angry exchange with the club's fans on the sidelines, is left on the bench due to a foot injury, with Joleon Lescott coming in at the back.
Aston Villa: Bunn; Bacuna, Okore, Lescott, Cissokho; Gueye, Westwood, Veretout, Gil, Ayew; Kozak
Subs: Guzan, Richard, Clark, Sinclair, Richardson, Lyden, Gestede
Crystal Palace: Hennessey; Ward, Dann, Delaney, Souare; Cabaye, Ledley, McArthur, Zaha, Puncheon; Sako
Subs: Speroni, Kelly, Jedinak, Mutch, Chamakh, Campbell, Wickham
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