The 43-year-old has used different formations in each of their opening four matches so far, and may decide to adjust again and adopt a 4-4-2 setup for this game.
Scaloni will also have to decide on which goalkeeper is to start. Franco Armani has played in all four qualifiers so far, however, a brilliant season for Emiliano Martinez at Aston Villa could see him given the nod on Friday.
River Plate right-back Gonzalo Montiel, who has also started in all four qualifiers, is expected to keep his place in the first XI, despite Tottenham Hotspur defender Juan Foyth impressing during his loan spell at Europa League winners Villarreal.
Norwich City playmaker Emiliano Buendia, who has received his first international call-up, is hoping to make his debut on Friday, though the 24-year-old is set to begin as a substitute.
Argentina possible starting lineup: E.Martinez; Montiel, Martinez Quarta, Otamendi, Tagliafico; Di Maria, Paredes, De Paul, Acuna; L.Martinez, Messi