The hosts sit at the foot of the table but have kept their survival hopes alive with back-to-back victories, while their opponents sit in 15th spot, one point and one place ahead of FC Emmen in the relegation playoff place and two points above the automatic drop zone with two games left to play.
ADO Den Haag have just about managed to keep their survival hopes alive with consecutive victories coming into this game, starting with an impressive win at home to Feyenoord.
The visitors took an early lead through Robert Bozenik, but a Jonas Arweiler goal and an Abdenasser El Khayati brace quickly turned the game on its head, while Nicolai Jorgensen's 70th-minute strike was not enough to salvage a point as Den Haag came out as 3-2 winners.
They then followed that up with a trip to PEC Zwolle, with another victory required to keep them in the fight to avoid the drop.
While they remain at the bottom of the table, De Residentieclub now sit just three points behind Thursday's opponents in 15th spot, which guarantees automatic safety, meaning a win would see them take a huge step towards avoiding the drop.
Willem II will look to record a crucial victory of their own on Thursday to see them fend off the bottom three going into the final game of the season.
They come into this game on the back of consecutive defeats, most recently falling to a 2-0 loss at home to second-placed PSV Eindhoven.
That means Zeljko Petrovic's side have now lost four of their last five league matches, seeing them fail to escape the battle for survival as a result.
With two games left to play, the Superkruiken find themselves just a single point ahead of Emmen in the relegation playoff place, and two points above the automatic drop zone.
That means a win over ADO Den Haag would not only see them move almost out of reach of the basement side, it could also confirm their survival, depending on other results at the bottom of the table.
Even if the teams around Petrovic's side pick up victories on Thursday, a victory would still be crucial in keeping them out of the bottom three and putting them in pole position to avoid the drop going into the final day of the season.
Ruud Brood only made one enforced change to his team last time out, as winger Vicente Besuijen served a one-game suspension, and he could keep a similar side again given their back-to-back victories.
That could see Besuijen return to the front three alongside Jonas Arweiler and Bobby Adekanye.
Striker Vangelis Pavlidis made a return to the Willem II starting lineup last time out, and he should lead the line again on Thursday, having netted nine Eredivisie goals so far this campaign.
Petrovic opted to move to a defensive-minded system of five at the back for the visit of PSV, but he should move back to a more usual lineup with four at the back on Thursday.
ADO Den Haag possible starting lineup:
Fraisl; Van Ewijk, Zuiverloon, Pinas, Kemper; De Boer, El Khayati, Goossens; Besuijen, Arweiler, Adekanye
Willem II possible starting lineup:
Muric; Owusu, Van Beek, Holmen, Kohn; Nunnely, Saddiki, Llonch, Ndayishimiye; Wriedt, Pavlidis
We say: ADO Den Haag 2-0 Willem II
In a game between two sides who will be absolutely desperate for a win in a crucial game in the race for survival, this encounter could definitely go either way, but we give the edge to the hosts.
Den Haag come into the match with momentum having kept their slim survival hopes alive with back-to-back wins, and we see them rallying to pick up a third straight victory to potentially move out of the bottom two.