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The Giants had the first chance to open the scoring as Josh Brown lined up a field goal attempt, but the kick was blocked to keep the tie scoreless early in the second quarter.
The home side finally opened the scoring when Manning tossed the ball to Victor Cruz, who completed a 23-yard run into the endzone for his first NFL touchdown in almost a year.
A Fitzpatrick interception just before the break brought the New York offense back into the field at the end of the second quarter, resulting in a short score for Rashad Jennings.
Manning re-established the Giants' advantage with a short pass to tight end Daniel Fells, while Fitzpatrick could only add a late consolation by running over from a couple of yards out.