The Bears got off to a good start as they scored on their opening drive, moving into the redzone seamlessly. The drive culminated in Jay Cutler finding tight end Martellus Bennett for a 12-yard touchdown.
Buffalo responded with a solid drive of their own as EJ Manuel found wide receiver Robert Woods for two plays and 49 yards before he went in for the touchdown himself with a two-yard run on a fake to his running back.
The Bills managed to take the lead as they capitalised on a turnover from Brandon Marshall, who fumbled the ball. Although the visitors didn't score seven, they did come away with points on the board courtesy of a Dan Carpenter field goal.
Buffalo extended their advantage as Corey Graham intercepted a pass from Cutler and drove his side into the redzone. The offense took over and put seven points on the board with a seven-yard pass from Manuel to CJ Spiller.
The Bears got themselves back on track with a field goal early in the third quarter through the boot of Robbie Gould and pulled themselves back to parity when Cutler found Marshall in the endzone for a 12-yard strike.
Both sides scored late field goals to take the game to overtime, but the Bills had just enough to edge out the Bears as they managed to engineer a scoring drive, with Carpenter kicking a game-winning field goal from 27 yards.