The 24-year-old, who reached the final of Indian Wells last week, had previously struggled on the low-bouncing grass courts.
However, he claimed a bronze medal at the Olympics last year, with that success aiding his hopes of silverware in June.
"I have a fantastic memory from last year when I won the bronze medal at the Olympics," he told reporters at a press conference.
"It was a magnificent experience for me. I had never played at an Olympics before so it was a big moment for me and my country. To win on grass at Wimbledon as well made it an even bigger moment.
"I think that if I play my best tennis I have a chance to win a grand slam on grass, but it will be very difficult."
Del Potro is currently ranked world number seven.