The five-time Major champion was competing in her first Grand Slam tournament since completing a suspension for doping, but after winning three matches at Flushing Meadows, the Russian lost out in three sets to Anastasija Sevastova on Sunday.
However, Sharapova has said that she is "proud" of her achievements in New York as she moved closer to regaining a place in the world's top 100 before the end of the year.
The 30-year-old is quoted by BBC Sport as saying: "It's been a really great ride in the last week.
"I can take a lot from this week. It's great to get that major out of the way. It was an incredible opportunity. I'm very thankful for the opportunity. I did my best. I can be proud of that."