The Scotsman, who has lost in four previous major finals, faces Novak Djokovic at Flushing Meadows tonight after overcoming Tomas Berdych in the last four.
Lendl, who himself lost in four finals before breaking his Grand Slam duck, believes that the lessons learned from Murray's quartet of defeats give him a better chance of victory than ever before.
He said: "If you look at his losses he has been beaten by Roger Federer three times and Novak Djokovic.
"After Wimbledon I said to him he should be proud of the way he handled the pressure because there was a big difference between that loss and the one he had to Djokovic in Australia the previous year.
"Andy is ready to go and win. The lesson he learned from the Wimbledon final was a tough one but he learned it well."
You can follow live commentary of Murray vs. Djokovic on Sports Mole tonight.