The German will take on Sara Errani for a place in the quarter-final at Flushing Meadows - an opponent that she has a 50% winning record against from their two matches.
As a result, Kerber feels that the outcome will be too close to call.
"I think that will be a very tough and close match," Kerber said. "I lost against her in Paris. I will just go out there and try to play my game and we'll see."