The world number two saw off the Serbian in under an hour to seal the 6-3 6-1 triumph.
"I always loved this tournament since I was a kid. One of my dreams was [to] play here," said Nadal. "It's a historic tournament [where] you see all your idols when you are a kid playing here.
"If you see the finals I win here, all the finals are against probably top-six players. That's something that makes the victories even more difficult."
The win was a record-breaking 20th Masters title for Nadal.