The captain was forced to start on the bench for last weekend's opening win over Italy following a shoulder injury.
Meanwhile, Luke Charteris has been ruled out due to a hamstring injury.
Wales team to face Ireland:
Leigh Halfpenny, Alex Cuthbert, Scott Williams, Jamie Roberts, George North, Rhys Priestland, Mike Phillips, Gethin Jenkins, Richard Hibbard, Adam Jones, Andrew Coombs, Alun Wyn Jones, Dan Lydiate, Sam Warburton, Taulupe Faletau
Replacements: Ken Owens, Paul James, Rhodri Jones, Jake Ball, Justin Tipuric, Rhys Webb, James Hook, Liam Williams