Both sides go into the clash off the back of successive victories and with hopes of overtaking England at the top of the table.
Wales beat Italy 26-9 in their last outing, but McBryde has said that taking on Scotland will be a different challenge.
"We've had a good week of preparation. The boys were on the ball this morning, it was good," he told Sky Sports News. "But Scotland are going to be a tough nut to crack.
"It's going to be a big challenge for us - Murrayfield is never an easy place to come. I think both teams are building momentum, based on the last two results and looking ahead to the next two games.
"We raised our game as a pack of forwards against Italy, and I think we are in a good place at the moment."
Wales sit second in the Six Nations table, two points behind England.