The Red Rose can claim a Grand Slam should they earn victory in Cardiff at the weekend, after extending their unbeaten run in the competition with an 18-11 victory over Italy on Sunday.
However, a winning margin of eight points or more will see the Dragons retain their crown, and Biggar insists that the stakes could not be higher.
"It does not get much bigger than this," Biggar told Sky Sports News.
"It will be a massive occasion and it will be hyped up by the press this week, but that is great and the way it should be.
"It is a title decider and we are not going to give up our hopes of the title. It remains within our grasp. It will be a difficult game, but one which we are relishing."
The two sides meet at the Millennium Stadium at the weekend.