The Ireland international, who missed the Six Nations with an ankle problem, has been dogged by a succession of injuries in recent seasons.
"Yeah, most probably at this stage - he is a great loss. I don't know if it is signed or sealed at this stage - that's for Stephen and his support team to make those decisions," Anscombe told UTV.
"We haven't had a lot of him this season because of injury, but he is a world-class player.
"Unfortunately we haven't had him all year really and the fact is when you have a player of that calibre you want them on the park, because they're a real concern for the opposition. It's been unfortunate but that's the way it is."
Ferris has made 35 appearances for his country.