London Irish have reshuffled their side, with George Skivington and Matt Garvey named in the lineup in place of Declan Danaher and Tom Homer.
Saints coach Jim Mallinder has made four changes in the forwards, with Dylan Hartley's eye injury seeing Phil Dowson drafted in to skipper the side.
The Northampton back line remains unchanged.
London Irish: Shingler, Ojo, Joseph, Tagicakibau, Yarde, Humphreys, O'Leary, Lahiff, Paice, Aulika, Skivington, Evans, Garvey, Gibson, Treviranus
Northampton Saints: Wilson, Pisi, Waldouck, Burrell, Artemyev, Myler, Dickson, Tonga'uiha, Haywood, Mujati, Manoa, Sorenson, Lawes, Wood, Dowson
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