France enter the match having lost both of their Six Nations matches thus far, but Saint-Andre is confident that they will rise to the "fantastic challenge".
"We will need to bring enthusiasm and confidence into the game. We will not beat England by doing nothing. Going to Twickenham is a fantastic challenge," he told reporters at a press conference.
"I want to be proud of a team who will go there to give 120% of what they have."
Saint-Andre has been widely criticised for his tactics in the tournament.