The same 23 players that lost 26-24 to France last weekend will travel to Edinburgh.
Both England and Scotland head into Saturday's match on the back of opening defeats.
England team to play Scotland:
Mike Brown (Harlequins), Jack Nowell (Exeter), Luther Burrell (Northampton), Billy Twelvetrees (Gloucestr), Jonny May (Gloucester), Owen Farrell (Saracens), Danny Care (Harlequins); Joe Marler (Harlequins), Dylan Hartley (Northampton), Dan Cole (Leicester), Joe Launchbury (London Wasps), Courtney Lawes (Northampton), Tom Wood (Northampton), Chris Robshaw (Harlequins, capt), Billy Vunipola
Replacements: Tom Youngs (Leicester), Mako Vunipola (Saracens), Henry Thomas (Sale), Dave Attwood (Bath), Ben Morgan (Gloucester), Lee Dickson (Northampton), Brad Barritt (Saracens), Alex Goode (Saracens)