Exeter Chiefs wing Nowell comes into the side in the place of Chris Ashton, who has been omitted from the 26-man squad.
Elsewhere, Gloucester winger Jonny May will win his second cap at the Stade de France, while Danny Care will start his first England game since playing against Italy in last year's tournament.
The pack remains unchanged from the team that started against New Zealand, with Joe Marler keeping his place in the side ahead of Mako Vunipola, who has been named on the bench.
England team to face France:
Mike Brown, Jack Nowell, Luther Burrell, Billy Twelvetrees, Jonny May, Owen Farrell, Danny Care; Joe Marler, Dylan Hartley, Dan Cole, Joe Launchbury, Courtney Lawes, Tom Wood, Chris Robshaw, Billy Vunipola
Replacements: Tom Youngs, Mako Vunipola, Henry Thomas, Dave Attwood, Ben Morgan, Lee Dickson, Brad Barritt, Alex Goode