Johnson has rotated his squad from the team that beat Wales at Twickenham.
"Last weekend's match was hugely competitive and we expect more of the same as we prepare to travel to the Millennium Stadium," Johnson said.
"We took a lot out of Saturday's game and this weekend gives the selected players their opportunity and a chance for us to improve our overall performance."
England team to play Wales:
B Foden, C Ashton, M Tindall (captain), S Hape, M Cueto; T Flood, R Wigglesworth, A Corbisiero, S Thompson, D Cole, L Deacon, C Lawes, T Wood, H Fourie, N Easter.
Replacements: L Mears, M Stevens, T Palmer, J Haskell, D Care, C Hodgson, M Banahan.