England enter the match having suffered defeat to Australia at the weekend and Lancaster has vowed to "get the selection right" this time around.
"The priority now is to get the selection right, with the physicality of the Springboks. Changes in personnel will give us some impetus," he told Sky Sports News.
"Ben Morgan scored a hat-trick at the weekend, James Haskell is desperate for an opportunity, Tom Wood is ready for a start, Alex Corbesiero is coming back. They will come into the equation."
However, Joe Marler has been ruled out of the clash with a knee injury.