The Leeds Rhinos back, 22, has not featured in either of England's opening two matches of the tournament.
Hardaker has been capped twice by his country following his debut last year.
An official England Rugby League statement read: "Due to personal issues, Zak Hardaker is unable to commit to the England Rugby League programme and has informed the England RL Management Team that he wishes to withdraw from the squad and will not play any further part in Rugby League World Cup 2013. No replacement has been called up."
England play their final group fixture on Saturday when they take on Fiji at the KC Stadium in Hull.