The 86-year-old will wed his personal secretary Gina Gonzalez, 36, who helped him prepare an autobiography in 2010.
"[I want to marry her] because I have been a widow for eight years," he told El Mundo. [I want to get married] as soon as possible, in two weeks or a month, I don't want to wait any longer.
"She is a Real Madrid fan - if she had been a Barcelona fan... I don't know! I'm sure my children will be against it and have a go at me but I will be sincere - if they ask me about it I will explain it to them."
Di Stefano, who is considered one of the finest strikers of his generation, was widowed eight years ago.