The American cyclist, who was stripped of his record seven Tour de France titles after the United States Anti-Doping Agency published a report accusing the Texan of doping throughout his career, gave a "no holds barred" interview with the Winfrey yesterday.
The former US TV chatshow host tweeted: "Just wrapped with @lancearmstrong More than 2 1/2 hours . He came READY!"
The Discovery Channel will air the interview at 2am Friday morning and again at 8pm Friday evening. Reports have claimed that Armstrong confessed to taking performance-enhancing drugs during his career in the programme.