The 29-year-old was dominant throughout the tournament and won by eight shots to clinch his second major title.
"To play here at Pinehurst with the history and the crowds, it's always very special," BBC Sport quotes Kaymer as saying.
"The way I played golf in the first two days was very good and fortunately I could bring it home. Overall, it was a very, very nice week for me and my main goal this year was the make the Ryder Cup team. I hope it's enough."
Kaymer is the first German winner of the Open and the fourth European winner in five seasons.