Captain Karl Henry is expected to keep his place in the starting lineup for the visit of the Tykes and the midfielder is hoping that his side can collect their first three points of the campaign.
"The one good thing about this league is that the games come thick and fast," he told the club's official website. "We've got an opportunity to get a win and if we do, we can put the Leeds defeat to bed."
One player that is unlikely to feature for the hosts is Steven Fletcher, whose future at Molineux remains uncertain. Matt Jarvis could also sit the match out as speculation grows regarding a transfer to either West Ham United or Everton.
Meanwhile, visiting Barnsley could hand a debut to Martin Cranie, who has recently been training with Leeds United.
Wolves: Ikeme; Zubar, Ward, Stearman, Johnson; Peseko, Doumbia, Henry, Edwards; Ebanks-Blake, Doyle
Barnsley: Gonzalez; Cranie, Foster, Wiseman, Stones; Etuhu, Perkins, Cywka, Mellis; Davies, Dawson
Sports Mole says: 2-0