The Championship's top two sides played out a heated 1-1 draw at Upton Park this evening.
Winston Reid should have given the Hammers the lead after eight minutes but fired over when presented with a simple put-away but they were soon ahead after an incident in the penalty area.
Noble eventually stepped up and converted the spot kick to put the Hammers ahead, although they would have to play the remaining 70 minutes with ten men.
As the half moved to a close, Southampton began to get into the game, with top scorer Ricky Lambert the Saints' main threat. The forward sent a free kick just wide of Robert Green's post three minutes before the break.
After the interval Lambert continued to look the most dangerous in a red-and-white shirt as the visitors pushed for an equaliser.
Both sides resume their positions at one and two in the table, with Cardiff City closing to within three points of second-placed Southampton.