The two clubs decided to make changes in the dugout during the middle of the season, and now find themselves deep in relegation trouble with seven games remaining.
They have each slipped down the table since swapping bosses, with the Baggies having only won once under Mel, who was a surprise appointment when he took over more than a month after Steve Clarke's sacking.
A 2-0 defeat to Hull City last weekend, partially inflicted by former striker Shane Long, left them 16th and only three points above the drop zone ahead of an old-fashioned 'six-pointer' against Cardiff.
The Bluebirds are one of the teams currently occupying the three relegation spots, and have a worse goal difference than their rivals, but victory this weekend could see them move level on points with West Brom.
They will take heart from giving Merseyside duo Everton and Liverpool scares in recent weeks, but a defence which has kept only two clean sheets in 16 top-flight games will be a concern to Solskjaer.
There could be a recall up front for either Matej Vyrda or Saido Berahino, with Espanyol loanee Thievy making way, while midfielder Graham Dorrans could continue his longest run in the team this season.
West Brom: LWLDDL
Possible starting lineups
West Brom: Foster; Reid, Dawson, Olsson, Ridgewell; Mulumbu, Morrison, Dorrans; Sessegnon, Berahino, Anichebe
Cardiff: Marshall; Fabio, Cala, Caulker, Theophile-Catherine, John; Medel, Kim, Mutch; Zaha, Campbell
Sports Mole says: 1-2