The Scot believes that the Magpies will need no motivation for the fixture following last Sunday's 3-0 defeat to Sunderland.
"The players are desperate to put the two defeats they've just had out the way and get back to picking up more points for the club," Clarke told reporters.
"Hopefully Newcastle will feel that. Newcastle should be wound up as well after a bad reverse last week in the derby game, so it should be an interesting fixture."
The Midlands outfit are currently eighth in the Premier League, six points behind Liverpool but with a game in hand.