Ledley, who made his international debut against Poland at the same venue in 2005, has said that it would be a "great honour" if he were selected to play.
"I am absolutely delighted and buzzing for Saturday," Ledley told Sky Sports News.
"It's a great honour for me and my family so I am looking forward to it and hopefully getting on the pitch for it. It's special for it to be at Cardiff City Stadium, where I came through the ranks and learnt all my football.
"When I was a kid I just wanted to play football and go out there and show the world I could do it. A lot of people do not make it to play for their country and it's a fantastic honour, and I try to do it as well as I can."
Ledley began his career with Cardiff City before joining Celtic in 2010.