Both sides have already been eliminated from Europe's top club competition, but just three points separate the two in the Group D table.
The Russian team's only win of this season's group stage came against the Czech champions earlier in the campaign, when they clinched a 3-2 victory.
Plzen will secure third place in the group at CSKA's expense if they win by more than one goal, or by a 1-0 or 2-1 scoreline.
Possible starting lineups
Plzen: Kozacik, Hubnik, Prochazka, Reznik, Rajtoral, Horava, Horvath, Pospisil, Duris, Tecl, Kolar
CSKA: Akinfeev, Ignashevich, Nababkin, Vasin, Karavev, Honda, Tosic, Wernbloom, Elm, Musa, Vitinho
Sports Mole says: 2-2