The 32-year-old has not turned out for the Three Lions since moving to the Major League Soccer outfit in February this year.
Defoe told BBC Sport: "I would never rule myself out of playing for my country. There's no better feeling than scoring goals for your country. To get that feeling again would be special."
He added: "I've always said as a player to get into any international squad is based on merit, you've got to playing well for your club and that's all you can do."
Defoe has scored 19 goals in 55 appearances for England.