The Swans have not won a league game since their 1-0 success over Newcastle United on March 2.
Southampton travel to South Wales unbeaten in their last five matches, a run which has eased their relegation fears. Last Saturday's 1-1 draw with West Ham United moved the Saints up to 12th place, seven points clear of the bottom three.
Swansea, who sit three points ahead of the visitors in ninth place, were last in action two weeks ago when they drew 2-2 at Norwich City.
Possible starting lineups
Swansea: Vorm; Tiendalli, Chico, Williams, Davies; Ki, De Guzman, Michu, Routledge, Dyer; Moore
Southampton: Boruc; Clyne, Hooiveld, Yoshida, Fox; Cork, Schneiderlin; Lallana, S Davis, Ramirez; Lambert
Sports Mole says: 2-1