The home side have taken just one point from their last six league games, with that run of form leaving them in 15th position in the table, just three points off the bottom three.
Swansea's home form has also been disappointing this season with five defeats and just two wins from their 11 matches on their own patch.
Meanwhile, Fulham sit in 17th position on 19 points. They have lost their last two matches in the league, but would move ahead of their opponents on Tuesday with victory.
That said, the London outfit have lost eight of their 11 league games on their travels this campaign, scoring just eight times in the process and conceding 26.
The corresponding match last season ended in a 3-0 win for Fulham, but Swansea were 2-1 winners when they travelled to Craven Cottage earlier in the campaign.
Swansea will have Spanish winger Pablo Hernandez to call upon in the league for the first time since New Year's Day after the former Valencia attacker recovered from a hamstring injury, but key trio Jonathan de Guzman, Nathan Dyer and Jonjo Shelvey are all expected to miss out.
Fulham, meanwhile, will ring the chances from their 1-1 draw in the FA Cup with Sheffield United.
Possible starting lineups
Swansea: Tremmel; Rangel, Chico, Williams, Davies; Britton, Amat, Pozuelo; Routledge, Bony, Hernandez
Fulham: Stekelenburg; Riether, Hangeland, Burn, Riise; Parker, Sidwell, Kasami; Kacaniklic, Berbatov, Dempsey
Sports Mole says: 1-1